Sesión 25 de febrero del 2014: Plasticidad en las células T.


Les envío un breve artículo para que no lleguen en blanco el martes.
Mariana Esther
El artículo: MurphyStockinger2010 y en ncbi.
Murphy, K. M., & Stockinger, B. (2010). Effector T cell plasticity: flexibility in the face of changing circumstances. Nature immunology, 11(8), 674-680.


As additional states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include their cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or alternately heterogeneous populations. New tools will be needed todefine the rules that allow or prohibit cellular transitions.