Sesión 24 de Sept: Topología del interactoma de la levadura

Hola a todos…

Les adjunto el artículo para el siguiente martes. Cumple con los requisitos, muchos dibujitos y dos de bibliografía, 🙂

Para la red:
Andre, X. C. N., V. Cusick y M. Cusick. 2006. Yeast Protein Interactome topology provides
framework for coordinated-functionality. Nucleic Acids Research, 34:9 2812–2819. DOI:10.1093/nar/gkl325.

Palabras clave: interactoma, interacción, proteína, topología, distribución, organización


Alejandra Zavala-Castillo

Abstract y liga al artículo.

The architecture of the network of protein–protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and ‘Q-modularity’. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pairwise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.